Canola & soy, not a smart choice

July 30, 2003

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" Steven Powers MD. " <steven.powers.md

Entrez-PubMed

ds=11593118 & dopt=Abstract

Medical Department, Ross Products Division, Abbott Laboratories, Columbus,

Ohio 43215-1724, USA. phyllis.acosta

BACKGROUND: Investigators in Italy and Spain have suggested that therapy for

patients with phenylketonuria (PKU) may result in essential fatty acid (EFA)

deficiency. Objectives of this study were to determine if the diets of

patients with PKU in the United States provided adequate EFA intakes and

whether patients could form long-chain polyunsaturated fatty acids. METHODS:

Patients (1-13 years of age) with classic PKU undergoing therapy and their

non-PKU sibling closest in age were compared. Nutrient intakes were

calculated from 3-day diet diaries. Fatty acids in plasma and erythrocytes

were identified and quantified. Paired t tests compared results for the

patients and their non-PKU siblings. RESULTS: Twenty-eight patients and 26

siblings were studied. Mean fat intake was greatest by siblings (34.8 +/-

1.3% of energy) and lowest by Phenyl-Free-fed patients (19.5 +/- 1.2% of

energy; P < 0.05). Fat intake (30.4 +/- 1.8% of energy) by Phenex-fed

patients did not differ from that of siblings. Percentage of energy ingested

as C18:2n-6 and C18:3n-3 did not differ significantly between patients and

siblings. No clinically significant, consistent differences were found in

fatty acid levels (wt%) in plasma or erythrocytes between patients with PKU

and siblings.

Lack of EFA deficiency in patients in this study may be the result of the

use of canola and soy oils containing C18:2n-6 and

C18:3n-3 rather than olive oil in the diets.

NCBI NLM NIH

Department of Health & Human Services

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