Cancer

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Dear Herbalists,

With the tendency to not clearly look at labelling any more - I

wanted to just give you the info about this chemical (which is in a lot

of products).............Love Penny

methylxanthine related fibrocystic breast disease

 

Benign breast disease and consumption of beverages containing

methylxanthines.

 

La Vecchia C, Franceschi S, Parazzini F, Regallo M, Decarli A, Gallus G,

Di Pietro S,

Tognoni G

 

The relationship between methylxanthine (Mx) consumption and benign

breast disease was

evaluated in a case-control study of 288 women with histologically

confirmed benign breast lumps

(203 dysplastic lesions and 85 benign tumors) and 2 groups of control

women--285 patients in the

hospital for acute conditions apparently unrelated to the consumption of

Mx-containing beverages

and 291 outpatients. The relative risk estimates of dysplastic breast

lesions (fibrocystic disease),

with allowance for all identified potential distorting factors, for

women who drank 1-2 or 3 or more

cups of coffee per day were 4.1 and 6.4, respectively, when the hospital

controls were the

comparison group and 2.0 and 3.7, respectively, when the outpatient

controls were the comparison

group. The relationship was even stronger when the total consumption of

Mx-containing beverages

(coffee plus tea) was considered and increased with increasing duration

of use. The association was

not explained by any of the major risk factors for fibrocystic breast

diseases or by differences in

general characteristics or other lifestyle habits between cases and

controls. Mx consumption was not

related to the risk of benign breast tumors (fibroadenomas). These

findings support the hypothesis

that Mx consumption is related to the risk of dysplastic lesions of the

breast.

 

PMID: 3858587, UI: 85211787

 

Clinical and biochemical studies on methylxanthine-related

fibrocystic breast disease.

 

Minton JP, Abou-Issa H, Reiches N, Roseman JM

 

The results of this study show that the consumption of methylxanthines

through dietary

sources appears to be associated with the etiologic development of

benign fibrocystic

disease in the American woman. Complete abstention from methylxanthine

consumption

resulted in complete resolution of the disease in 82.5% and significant

improvement in

15% of those studied. Thus 97.5% showed clinical benefit from total

methylxanthine

abstention. The results of a clinical questionnaire answered by 500

women consuming

methylxanthines, one half of whom had fibrocystic breast disease,

suggest that women

with fibrocystic disease may have a genetic predisposition for both

benign breast disease

and cancer. Biochemical studies implicate increased sensitivity of the

adenylate cyclase

system to catecholamines in patients with fibrocystic disease.

Methylxanthines are known

to increase circulating catecholamines.

 

PMID: 7256542, UI: 81249832

Methylxanthines and fibrocystic breast disease: a study of correlations.

 

Bullough B, Hindi-Alexander M, Fetouh S

 

School of Nursing, State University of New York-Buffalo.

 

Daily methylxanthine ingestion from drug and dietary sources was studied

by means of

questionnaires from a sample of 102 women who visited the office of a

radiologist for

xeromammograms. The mammograms were used to measure the level of

fibrocystic breast disease.

Fibrocystic breast disease was found to be positively correlated with

both caffeine and total

methylxanthine ingestion. These positive findings are discussed in light

of the fact that most recent

studies of this link have been negative.

 

PMID: 2314678, UI: 90191319