Guest guest Posted October 28, 2000 Report Share Posted October 28, 2000 Lobelia inflata (Indian tobacco, Puke weed) Therapeutic Actions: * Inhibits cardioactivity (slowing pulse rate and blood pressure) followed by increased pulse and blood pressure in small doses * Lowers carbon dioxide threshold to increase respiration * Produces pain and nausea in moderate doses * Promotes gastric secretions and is a stimulant in small doses * Promotes mucous secretions in respiratory passages * Powerful and exhausting emesis followed by profound relaxation in large doses * Sialagogue * Stimulates autonomic ganglia followed by depression * Stimulates preganglionic nicotinic receptors and secondarily depresses them * Stimulates respiratory centers in small doses and paralyzes respiration in large doses * Thins tenacious mucous Clinical Indications: * Asthma * Bronchitis * Cholecystitis * Cholelithiasis * Rheumatoid arthritis - pain * Angina pectoris pain * Bradycardia * Contact dermatitis from poison oak, insect bites and stings (use topically) * Contusion pain * Dyspnea * Emetic * Gastric stimulant to augment appetite and stimulate peristalsis * Muscle spasms * Muscular rigidity during labor * Neuralgia * Nicotine withdrawal due to the similarity to nicotine on autonomic ganglia * Orchitis pain * Pharyngitis pain * Pleurisy * Pleurodynia * Tonsillitis pain * Whooping cough Contraindications: * Asthma of cardiac decompensation,'hypertension' sinus arrhythmia or bundle branch block * Avoid in the very young and elderly * Decompensation * Dyspnea from enlarged or fatty heart * Hydropericardium * Hydrothorax * Hypertension * Nervous prostration * Paralysis * Poisoning with a depressing substance * Pregnancy due to similarity of lobeline to nicotine * Shock * Valvular incompetence of the heart Drug/Nutrient Interaction: * Limited data Chemical Constituents: * Chelidonic acid * Gum * Lipids * Lobelic acid * Pyridine alkaloids: Lobelanidine Lobelanine Lobeline * Resin * Volatile oil Toxicity: * 1 drop of lobeline alkaloid causes vomiting * Toxic levels usually product vomiting, lessening the results * Symptoms include: Convulsions Diarrhea Hypothermia Mental confusion Nausea and vomiting Pinpoint pupils Paralysis Salivation Stupor Tachypnea Tremors Death due to respiratory paralysis * Antidote: Activated charcoal in water by mouth Atropine: 2 mg. subcutaneous Gastric lavage Saline cathartics and fluids Quote Link to comment Share on other sites More sharing options...
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