chelated minerals and mood disorders research + powdered mineral supplement site

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Effective mood stabilization with a chelated mineral

supplement: an open-label trial in bipolar disorder.

 

Kaplan BJ, Simpson JS, Ferre RC, Gorman CP, McMullen

DM, Crawford SG.

 

Faculty of Medicine, University of Calgary, Alberta

Children's Hospital, Canada. kaplan

 

BACKGROUND: To determine in open trials the

therapeutic benefit of a nutritional supplement for

bipolar disorder. METHOD: The sample consisted of 11

patients with DSM-IV-diagnosed bipolar disorder aged

19 to 46 years, who were taking a mean of 2.7

psychotropic medications each at study entry. Three

additional patients dropped out prematurely. The

intervention is a broad-based nutritional supplement

of dietary nutrients, primarily chelated trace

minerals and vitamins, administered in high doses. At

study entry and periodically thereafter, patients were

assessed with the Hamilton Rating Scale for Depression

(HAM-D), the Brief Psychiatric Rating Scale (BPRS),

and the Young Mania Rating Scale (YMRS). RESULTS: For

those who completed the minimum 6-month open trial,

symptom reduction ranged from 55% to 66% on the

outcome measures; need for psychotropic medications

decreased by more than 50%. Paired t tests revealed

treatment benefit on all measures for patients

completing the trial: HAM-D mean score at entry =

19.0, mean score at last visit = 5.4, t = 5.59, df =

9, p < 01; BPRS mean score at entry = 35.3, mean score

at last visit = 7.4, t = 2.57, df = 9, p <.05; YMRS

mean score at entry = 15.1, mean score at last visit =

6.0, t = 4.11, df = 9, p < .01. The effect size for

the intervention was large (> .80) for each measure.

The number of psychotropic medications decreased

significantly to a mean +/- SD of 1.0+/-1.1 (t = 3.54,

df = 10, p < .01). In some cases, the supplement

replaced psychotropic medications and the patients

remained well. The only reported side effect (i.e.,

nausea) was infrequent, minor, and transitory.

CONCLUSION: Some cases of bipolar illness may be

ameliorated by nutritional supplementation. A

randomized, placebo-controlled trial in adults with

bipolar I disorder is currently underway, as well as

open trials in children.

 

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