Prostate Cancer Adjuvant Therapy Protocol

[Guest guest]

 

[cancercured] [Fwd: Prostate Cancer Adjuvant Therapy Protocol]-------Prostate Cancer Adjuvant Therapy ProtocolThu, 2 Dec 2004 17:58:51 ESTSome may find this of interestEd BrennerLife Extension Update December 2 2004In this issue, December 2 2004: Life Extension Update Exclusive: Teapolyphenols' mechanism for halting prostate tumor growth and metastasis revealed; Protocol: Prostate Cancer Adjuvant Therapy; Featured Products:Mega Green Tea Extract, Mega Green Tea Extract Decaffeinated; Life Extension Magazine December 2004 issue now onlineLife Extension Update ExclusiveTea polyphenols’ mechanism for halting prostate tumor growth and metastasisrevealedA study published in the December 1 2004 issue of the journal Cancer Research(http://cancerres.aacrjournals.org/ ) revealed mechanisms by whichpolyphenols derived from green tea not only help prevent the growth of tumors, but aid in preventing their spread.Researchers from the University of Wisconsin and Case Western ReserveUniversity in Cleveland, Ohio, supplied mice bred to develop prostate cancer with drinking water to which green tea polyphenols had been added over a twenty-four week period. A control group received water without any additives. The mice used in the study had been the subjects of previous research which found an inhibition in prostate cancer and development when the animals were give tea polyphenols.The current study found a decrease in insulin-like growth factor-1 ( (IGF-1)and an increase in insulin-like growth factor binding protein (IGFBP3) in theprostate glands of the mice who received green tea polyphenols, as

well asinhibition of specific cell survival proteins. Elevations of IGF-1 anddecreases in its binding protein have been found to be associated with cancer in thismodel as well as with an increased risk of some human cancers.The team also found that markers of metastasis were reduced. In addition,vascular endothelial growth factor, a polypeptide that forms new blood vessels,was lowered following treatment with green tea polyphenols. The formation ofnew blood vessels, or angiogenesis, is necessary for a tumor to receivenutrients and grow.Senior author Hasan Mukhtar, PhD, of the Department of Dermatology at theUniversity of Wisconsin, stated, "These observations bear significance in lightof studies that indicate increased levels of IGF-1 are associated withincreased risk of several cancers, such as prostate, breast, lung and colon."The authors “suggest that IGF-I/IGFBP-3 signaling

pathway is a prime pathwayfor green tea polyphenol-mediated inhibition of prostate cancer that limitsthe progression of cancer through inhibition of angiogenesis and metastasis.â€ProtocolProstate Cancer Adjuvant TherapyThe inhibition of new blood vessel formation to block the growth and spreadof prostate cancer (PC) is currently under investigation. Androgen deprivationtherapy (ADT) is known to have this antiangiogenesis effect as well as genistein. Other agents that have an effect on cancer cell invasiveness include green tea polyphenols. Green and black tea are derived from the same plant,Camellia sinensis. However, only green tea is rich in the flavonol group ofpolyphenols known as catechins. The fermentation process used in making black tea destroys the biologically active polyphenols of the fresh leaf. The catechins as a group have significant free radical scavenging ability and are potent

antioxidants. Four catechins are found in green tea leaves:epicatechin (EC)epigallocatechin (EGC)epicatechin gallate (ECG)epigallocatechin gallate (EGCG)Of these four factions EGCG is the most important to the PC patient.Pharmacological activity extends beyond its actions as an antioxidant and free radical scavenger. Epigallocatechin-3 gallate (EGCG) acts against urokinase, anenzyme often found in large amounts in human cancers (Jankun et al., Nature, 1997).Urokinase breaks down the basement membrane of cell junctions, which may be akey step in the process of tumor cell metastasis, as well as tumor growth(Ennis et al., Proc. Annu. Meet. Am. Assoc. Cancer Res., 1997). EGCG attaches tourokinase and prevents these actions.GTP also inhibits ornithine decarboxylase (ODC), resulting in a decrease inpolyamine synthesis and cell growth (Carlin et al., J. Urol., 1996). Inhibitorsof

5-alpha-reductase (5AR) may be effective in the treatment of5-alpha-dihydrotestosterone-dependent abnormalities, such as benign prostate hyperplasia, PC, and certain skin diseases. The green tea catechins are potent inhibitors of type-1 but not type-2 5AR (Liao and Hiipakka, Biochem. Biophys. Res. Commun., 1995). They also inhibit accessory sex gland growth in rats. These results suggest the certain tea gallates can regulate androgen action in target organs. The 5AR inhibitor Proscar is predominantly a type-2 inhibitor.Long-term consumption of tea catechins is common in China and Japan. Thefrequency of the latent, localized type of PC does not vary significantly between Eastern and Western cultures, but the clinical incidence of metastatic PC is generally lower in Japan and other Asian countries, in contrast to the common occurrence of metastatic PC in Europe and the United States.http://www.lef.org/protocols/prtcl-134.shtml**********************************************All Contents Copyright © 1995-2004 Life Extension Foundation. All RightsReserved.-- Are you digging your grave with your teeth?Read Hundreds of Collected Cancer Testimonials and learn:http://curezone.com/forums/fd50.asp?f=2Learn more about cancer:http://curezone.com/diseases/cancer/http://curezone.com/diseases/cancer/faq.aspYou are receiving this email because you elected to to the cancercured . To from this list, simply send blank e-mail message to: cancercured-nomail To post message: cancercured To :

cancercured- To change status to digest: cancercured-digest To change status to normal: cancercured-normal By joining the list you agree to hold yourself FULLY responsible FOR yourself!List Archives: cancercured/messages/