Vitamin D Intake too low-S/B at least 2000 IU/day

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FOR IMMEDIATE RELEASE

Orthomolecular Medicine News Service, February 19, 2010

Official Recommended Intake for Vitamin D is Too Low

2,000 IU/Day or More Needed for Optimal Health

by William B. Grant, Ph.D.

(OMNS, Feb 19, 2010) Vitamin D has been a natural part of man's experience

forever, and 90% of vitamin D is derived from solar ultraviolet-B (UVB)

irradiance. The health effects of vitamin D can be and have been determined

from a variety of studies including ecological, observational (case-control

and cohort), and cross-sectional studies.

Vitamin D helps both to prevent and to treat chronic diseases including

many types of cancer, cardiovascular disease (coronary heart disease, stroke,

etc.), congestive heart failure, diabetes mellitus (types 1 and 2),

osteoporosis, falls, and fractures. It is also effective against infectious

diseases including both bacteria and viral infections: bacterial vaginosis,

pneumonia, dental caries, periodontal disease, tuberculosis, sepsis/septicemia,

Epstein-Barr virus, and influenza type A such as A/H1N1 influenza. The

autoimmune diseases include asthma, type 1 diabetes mellitus, multiple

sclerosis, and perhaps rheumatoid arthritis.

Pregnancy outcomes are also adversely affected by low serum D levels. 40%

of primary Cesarean-section deliveries in the United States are linked to

low D levels (9% of births in the United States involve primary C-section),

and preeclampsia is also linked to low serum levels of D. In regards to

cancer, vitamin D helps cells fit into the organs properly or commit suicide

(apoptosis), and also reduces angiogenesis (new blood vessel growth) around

tumors and reduces metastasis. For metabolic diseases, the mechanisms

include increased insulin sensitivity and insulin production. For infectious

diseases, vitamin D induces production of cathelicidin and defensins, which

have antimicrobial and antiendotoxin activities.

Due to current lifestyles in the United States, most people do not spend

sufficient time in the sun to produce the higher serum D levels associated

with optimal health. Black-Americans are particularly vulnerable to low

levels due to their darker skin, which reduces the amount of UVB that reaches

the 7-dehydrocholesterol in the lower epidermis to produce previtamin D.

Black-Americans have a 25% higher mortality rate than White-Americans, and

this difference may be explained in terms of lower serum 25(OH)D levels. Solar

UVB is an excellent source of vitamin D during about half of the year. The

way to take advantage of the sun as a source of vitamin D is to expose as

much of the body as possible without sunscreen near solar noon, the time

when one's shadow is shorter than one's height, for 10-30 minutes depending

on skin pigmentation, being careful not to turn pink or red or burn. (

_http://www.doctoryourself.com/holick.html_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.doctoryourself.com/holick.html)

)

Supplements represent an efficient way to obtain sufficient vitamin D.

African-Americans should consider taking 3000 International Units (IU) per day

while White-Americans should consider taking 2000 IU/day. The current

dietary guideline, approximately 400 IU/day, was based on the amount of vitamin

D in a spoonful of cod liver oil, which prevented rickets.

There are few adverse effects of vitamin D. With whole-body exposure to

the sun, one can make at least 10,000 IU/day in a short time. Adverse effects

such as hypercalcemia have been found in general only for 20,000-40,000

IU/day for very long periods. However, those with certain diseases such as

adenoma of the parathyroid gland, granulomatous diseases, lymphoma,

sarcoidosis, and tuberculosis, should limit their vitamin D intake or

production due

to the fact that the body's innate immune system produces too much

1,25-dihydroxyvitamin D in the serum, which can raise serum calcium levels too

high.

Several studies have examined how much mortality rates and economic

burdens of disease could be lowered if the population had more vitamin D. These

studies were for Western Europe, Canada, the Netherlands, and the United

States. They generally found that mortality rates could be reduced by about

15%.

During pregnancy and lactation, women should be taking about 6000 IU/day.

The current US " Adequate Intake " recommendation is a mere 200 IU/day. Bruce

W. Hollis and Carol L. Wagner, Medical University of South Carolina,

recently completed a randomized controlled trial vitamin D supplementation for

pregnant and nursing women and found that even 2000 IU/day was inadequate,

and that there were no adverse effects with 6000 IU/day.

For the text of a Vitamin D Scientists' Call to Action, please go to

_http://www.grassrootshealth.net_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.grassrootshealth.net) .

[William B. Grant earned his PhD in physics at UC Berkeley. For 15 years

he was a physicist at NASA Langley Research Center's Atmospheric Sciences

Division. He has authored or coauthored over 180 papers in peer reviewed

journals. Since he began his work on UVB/vitamin D and cancer in 2000, the list

of vitamin D-sensitive cancers has grown from 5 to at least 16. His paper

in Cancer in 2002 identified 10 additional vitamin D-sensitive cancers. Dr.

Grant directs the Sunlight, Nutrition, and Health Research Center (SUNARC)

_http://www.sunarc.org_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.sunarc.org) .]

For Further Reading:

[No authors listed]. Vitamin D - monograph. Altern Med Rev. 2008

Jun;13(2):153-64. _http://www.thorne.com/altmedrev/.fulltext/13/2/153.pdf_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.thorn

e.com/altmedrev/.fulltext/13/2/153.pdf)

Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal

vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol

Metab. 2007 Sep;92(9):3517-22.

_http://jcem.endojournals.org/cgi/reprint/92/9/3517_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--jc\

em.endojournals.org/cgi/reprint/92/9/3517)

Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med

Rev. 2008 Mar;13(1):6-20.

_http://www.thorne.com/altmedrev/.fulltext/13/1/6.pdf_

(http://www.thorne.com/altmedrev/.fulltext/13/1/6.pdf)

Dietrich T, Joshipura KJ, Dawson-Hughes B, Bischoff-Ferrari HA.

Association between serum concentrations of 25-hydroxyvitamin D3 and

periodontal

disease in the US population. Am J Clin Nutr. 2004 Jul;80(1):108-13.

_http://www.ajcn.org/cgi/reprint/80/1/108_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ajcn.org/cgi/reprint/80/1/108)

Dunning JM. The influence of latitude and distance from seacoast on dental

disease. J Dent Res. 1953 Dec;32(6):811-29.

_http://jdr.sagepub.com/cgi/reprint/32/6/811_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--jd\

r.sagepub.com/cgi/reprint/32/6/811)

East BR. Mean annual hours of sunshine and the incidence of dental daries.

Am J Public Health Nations Health. 1939 Jul;29(7):777-80.

_http://www.ajph.org/cgi/reprint/29/7/777_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ajph.org/cgi/reprint/29/7/777)

Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick

MF. The role of vitamin D in cancer prevention. Am J Public Health. 2006

Feb;96(2):252-61. _http://www.ajph.org/cgi/reprint/96/2/252_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ajph.org/cgi/r

eprint/96/2/252)

Giovannucci E, Liu Y, Rimm EB, Hollis BW, Fuchs CS. Stampfer MJ, Willett

WH. Prospective study of predictors of vitamin D status and cancer incidence

and mortality in men. JNCI 2006; 98:451-9.

_http://jnci.oxfordjournals.org/cgi/reprint/98/7/451_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--jn\

ci.oxfordjournals.org/cgi/reprint/98/7/451)

Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of

myocardial infarction in men: a prospective study. Arch Intern Med. 2008

Jun 9;168(11):1174-80. _http://archinte.ama-assn.org/cgi/reprint/168/11/1174_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http-

-archinte.ama-assn.org/cgi/reprint/168/11/1174)

Grant WB. How strong is the evidence that solar ultraviolet B and vitamin

D reduce the risk of cancer? An examination using Hill's criteria for

causality. Dermato-Endocrinology. 2009;1(1):17-24.

_http://www.landesbioscience.com/journals/dermatoendocrinology/article/7388/_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.landesbioscience.com/jo

urnals/dermatoendocrinology/article/7388/)

Grant WB. In defense of the sun: An estimate of changes in mortality rates

in the United States if mean serum 25-hydroxyvitamin D levels were raised

to 45 ng/mL by solar ultraviolet-B irradiance. Dermato-Endocrinology,

2009;1(4):207-14.

_http://www.landesbioscience.com/journals/dermatoendocrinology/archive/volume/1/\

issue/4/_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.landesbioscience.com/journals/dermatoendocri

nology/archive/volume/1/issue/4/)

Grant WB, Cross HS, Garland CF, Gorham ED, Moan J, Peterlik M, Porojnicu

AC, Reichrath J, Zittermann A. Estimated benefit of increased vitamin D

status in reducing the economic burden of disease in Western Europe. Prog

Biophys Mol Biol. Prog Biophys Mol Biol. 2009 Feb-Apr;99(2-3):104-13. (posted

at

_http://www.sunarc.org_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.sunarc.org) )

Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81.

_http://content.nejm.org/cgi/content/short/357/3/266_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--co\

ntent.ne

jm.org/cgi/content/short/357/3/266)

Hyppönen E, Power C. Hypovitaminosis D in British adults at age 45 y:

nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr.

2007 Mar;85(3):860-8. _http://www.ajcn.org/cgi/reprint/85/3/860_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ajcn.org

/cgi/reprint/85/3/860)

Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D

and calcium supplementation reduces cancer risk: results of a randomized

trial. Am J Clin Nutr. 2007 Jun;85(6):1586-91.

_http://www.ajcn.org/cgi/reprint/85/6/1586_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ajcn.org/cgi/reprint/85/6/1586)

Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA.

Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared

with 2000-2004. Am J Clin Nutr. 2008 Dec;88(6):1519-27.

_http://www.ajcn.org/cgi/reprint/88/6/1519_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ajcn.org/cgi/reprint/88/6/1519)

Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A,

Levine B, Mehrotra R, Norris K. Prevalence of cardiovascular risk factors

and the serum levels of 25-hydroxyvitamin D in the United States: data from

the Third National Health and Nutrition Examination Survey. Arch Intern Med.

2007 Jun 11;167(11):1159-65.

_http://archinte.ama-assn.org/cgi/reprint/167/11/1159_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ar\

chinte.ama-assn.org/cgi/reprint/167/11/1159)

Melamed ML, Michos ED, Post W, Astor B. 25-hydroxyvitamin D levels and the

risk of mortality in the general population. Arch Intern Med. 2008 Aug

11;168(15):1629-37._http://archinte.ama-assn.org/cgi/reprint/168/15/1629_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ar\

ch

inte.ama-assn.org/cgi/reprint/168/15/1629)

Merewood A, Mehta SD, Chen TC, Bauchner H, Holick MF. Association between

vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab.

2009 Mar;94(3):940-5.

Papandreou D, Malindretos P, Karabouta Z, Rousso I. Possible Health

Implications and Low Vitamin D Status during Childhood and Adolescence: An

Updated Mini Review. Int J Endocrinol. 2010;2010:472173.

_http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778445/pdf/IJE2010-472173.pdf_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.ncbi.nlm.nih.gov/pm

c/articles/PMC2778445/pdf/IJE2010-472173.pdf)

Schwalfenberg G. Not enough vitamin D: health consequences for Canadians.

Can Fam Physician, 2007;53(5):841-54.

_http://www.cfp.ca/cgi/reprint/53/5/841_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ww\

w.cfp.ca/cgi/reprint/53/5/841)

Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin

EJ, D'Agostino RB, Wolf M, Vasan RS. Vitamin D deficiency and risk of

cardiovascular disease. Circulation. 2008 Jan 29;117(4):503-11.

_http://circ.ahajournals.org/cgi/content/full/117/4/503_

(http://www.cihfimediaservices.org/12all/lt/t_go.php?i=54 & e=MjYyMjM= & l=-http--ci\

rc.ahajournals.org/cgi/content/f

ull/117/4/503)

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