Oxygen, Ozone, & Hydrogen Peroxide

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Oxygen, Ozone, & Hydrogen Peroxide

 

By Majid Ali, M.D.<majidalimd

_http://educate-yourself.org/cancer/ozonebymajidli17jul03.shtml_

(http://educate-yourself.org/cancer/ozonebymajidli17jul03.shtml)

July 17, 2003

 

(Abridgement from The Journal of Integrative Medicine article:

Oxidative

Regression To Primordial Cellular Ecology (ORPEC))

The author's clinical experience has led him to conclude that

oxygenative

antioxidant therapies such as nasal oxygen and intravenous

infusions of

ozone-oxygen gas mixture and hydrogen peroxide are among the most

beneficial

therapies for reversing the ORPEC state.

Since oxygen, ozone and hydrogen peroxide act as oxidants in a

laboratory

setting, therapies employing those agents are generally deemed

oxidative

therapies.191-193 Until recently, the author accepted that view

uncritically.

However, it is clear from studies presented in this article that

this is a gross

error. In reality, such therapies in the context of the ORPEC state

are

powerful oxygenative and antioxidant therapies. The reason for that

widespread

misconception is the failure to clearly understand the complex

biologic

consequences of adding oxygen, ozone, and hydrogen peroxide to

severely impaired

enzymatic and cellular ecosystems in patients with accelerated

oxidative injury.

A Burst of Thunderstorm, A Burst of Oxidants

 

An analogy of a burst of thunderstorm may be used to explain the

possible

mechanism action of ozone. The still air in a city on a hot, humid

summer

afternoon is thick with stagnant smog. The traffic on city streets

is snarled.

Tree leaves are dry and limp. Many persons are distressed by air

pollution.

Suddenly, dark clouds loom large and bring a heavy thunderstorm.

Strong winds

push out the polluted air. Tree leaves are bombarded by heavy

rains. The healthy

and robust leaves of trees withstand the storm well, while older

and

weakened leaves are severely damaged. Many withering leaves on tree

brances are

blown away. After the thunderstorm subsides, the air is clean and

crisp. The

trees looked washed, their leaves fresh and shiny. Bursts of

intravenously

injected ozone and hydrogen peroxide affect the blood elements the

same way. The

membranes of healthy erythrocytes withstand the oxidative stress of

ozone and

hydrogen peroxide well, recovering their normal morphology after

initial

membrane deformities. The senescent cells, by contrast, shrink and

undergo lysis.

Below, some theoretical, clinical and experimental considerations

are

presented that shed light on the apparent paradox of agents that

are oxidizing in

their essential roles, and yet provide the basis for oxygenative

antioxidant

therapies.

Intermittent Nasal Oxygen

 

The oxygenative role of nasal oxygen is self-evident. Oxygen is

also a

powerful oxidizer, as discussed earlier in the section devoted to

spontaneity of

oxidation in nature. The ORPEC hypothesis provides a clear

scientific basis

for oxygen's ability to also serve the opposing antioxidant role.

As discussed

earlier, anoxia increases oxidative stress directly by facilitating

the

generation of toxic reactive species as well as indirectly by

causing acidosis.

In this author's clinical experience, the use of intermittent nasal

administration of oxygen (2.5 to 3.5 L/min given for periods of one

hour two or three

times a day) benefits most patients in the ORPEC state. It is also

the

opinion of the author that oxygen therapy is very underutilized in

the care of

patients in the ORPEC state, such as those with fibromyalgia,

chronic fatigue

state, severe autoimmune disorders, and spreading malignant tumors.

Oxygen is

readily and inexpensively available to all patients. Also available

are

inexpensive portable rental units that may be used in travel as

well.

When used intermittently and in moderate doses as described here,

this

therapy has been found to be completely free of adverse effects.

The author also

has limited experience with oxygen therapy in patients with severe

pulmonary

emphysema and pulmonary interstitial fibrosis. Evidently, the use

of oxygen in

such patients must be monitored closely so that oxygen therapy does

not

cause further deterioration in the function of central sensors for

oxygen and

carbon dioxide.

Intravenous Ozone Therapy

 

Ozone is triatomic oxygen with a high electrovoltaic potential.

Ozone gas

infused intravenously at the Institute consists of a gaseous

mixture with

oxygen containing a very low concentration of ozone. It is prepared

by passing

pure oxygen through a high voltage field. The concentration of

ozone generated

depends on the rate of flow of oxygen as well as on the conditions

of voltage

and spacing of electrodes. The gaseous mixture used in our clinical

practice

is titrated to contain from 0.3 to 2.5% (30 to 50 ug O3/ml O2).

Thus,

intravenously administered " ozone " in reality represents 97 to

99.7% of pure

oxygen.

Practitioners who have never administered ozone gas mixture

intravenously

often express concern about the possibility of air embolism caused

by gas

infusion. Such concern is totally unwarranted. Pure oxygen and

ozone diffuse

immediately into the blood and do not persist as gases. The author

has tested for

that on numerous occasions by injecting 2 ml of the ozone mixture

into a

large vein, then immediately drawing the blood back. Except on

uncommon

occasions, the blood drawn back from the vein is pink (ozone turns

dark venous blood

into pink blood) and free of any gas bubbles. One can safely

presume that the

process of dissolution of the gas mixture would be complete by the

time it

reaches the large veins in the thorax.

Another concern expressed by those unfamiliar with the clinical

uses of

ozone mixture is the toxicity of ozone as discussed by

environmentalists. It must

be recognized that those individuals are perturbed by the products

of

reaction of ozone with other ecopollutants such as oxides of

nitrogen. Ozone is a

highly reactive molecule. Indeed, ozone owes its many antiviral,

antibacterial, and antifungal properties to this aspect of this

specific aspect.

Microscopic Evidence for the Antioxidant Role of Intravenous Ozone

Therapy

In the concentration used our in clinical practice, ozone causes

temporary

and reversible erythrocyte membrane damage as evidenced by clumping

and red

cell membrane deformity. The evidence for the oxidative nature of

such

erythrocyte membrane deformities has been previously demonstrated

by the

reversibility of such changes with antioxidants such as ascorbic

acid, tocopherol, and

taurine.56,57

How may the observed overall invivo antioxidant effects of ozone, a

powerful

invitro oxidant, be explained? Ozone has well established effects

of

improving tissue perfusion and cellular oxygenation.67 Just as the

duality of oxygen

allows it to be a molecular Dr. Jekyll and Mr. Hyde, reactive

oxidant

species also play dual roles. Not only do they inflict oxidative

damage to enzymes,

induce mutations, and damage cell membranes, they also serve many

useful

functions such as modulation of cellular redox dynamics, activation

of gene

transcription, signal transduction, and apoptosis.93-95 It seems

that ozone

evokes an upregulatory response from cell membrane-associated

antioxidant enzyme

systems just as all oxidants do from all biologic antioxidant

systems. Though,

direct quantitative data for those effects are not yet forthcoming.

One may

also, with good reason, speculate that ozone elicits similar

responses from

other matrix- and cell organelle-related antioxidant systems. There

is yet an

other important mechanism by which ozone protects patients with

chronic

illnesses from accelerated oxidative stress. Viruses, bacteria,

fungi, PLFs and

parasite inflict cellular injury by causing oxidative stress. Ozone

also is a

well established antiviral, antibacterial, and antifungal agent.58-

63. Ozone

through its powerful antimicrobial effects reduces the overall

oxidative

stress on persons with chronic viral, bacterial, fungal and PLF

overgrowth

syndromes. Thus, the ORPEC hypothesis carries strong explanatory

power for the

empirically observed biologic antioxidant effects of ozone.

Intravenous Hydrogen Peroxide Therapy for the ORPEC State

 

The biologic antioxidant effects of hydrogen peroxide, a potent

oxidizer

like ozone, are mediated by all the mechanisms cited for ozone in

the preceding

section. The clinical benefits of hydrogen peroxide infusions

observed at the

Institute in patients with fibromyalgia and chronic fatigue

syndrome are the

subject of a separate report.72

Reference from the complete article in The Journal of Integrative

Medicine

1998;2:4-55

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