Guest guest Posted July 29, 2008 Report Share Posted July 29, 2008 From Carol Wohar: HOW TO DO A LIQUID TITRATION TO REDUCE A DRUG (not to be done with an extended release drug) [The starting dose of 10mg here is just for an example of how to do a 10% reduction. You can still use the same amount of liquid and the same-sized syringe regardless of what dosage you are taking. The only thing that changes is the amount you dissolve. You merely need to multiply your dose by 10% (or 5% if you need to go more slowly) by changing the percentage to a decimal. This is done by removing the percent sign and placing a decimal poiint two places to the left. EXAMPLE: 10% become .10 5% becomes .05 Then, multiply your current dose by the amount you wish to decrease (.05 or ..10). Let's say your current dose is 25 mg. EXAMPLE: 25 x .10 = 2.5 25 x .05 = 1.25 Then, subtract the answer you get from your current dose of 25 mg. EXAMPLE: If you wish to reduce by 10%: 25.0 - 2.5 = 22.5 mg 22.5 mg. is the dose you will take if you wanted to reduce by 10%. EXAMPLE: If you wish to reduce by 5%: 25.0 - 1.25 = 23.75 mg 23.75 mg. is the dose you will take if you wanted to reduce by 5%. Go to a pharmacy and getting a 10 mL monoject syringe without the needle tip. Also you will need a 1 Ml B-D syringe without the needle tip. (With these two syringes you can measure to the 1/10 of a mL and less) My pharmacist gave me both of these syringes. You would then disolve your 10 Mg pill in 10mL of liquid. This may be water, club soda, hot water, or anything else in which your pill will completely dissolve. you'll need to experiment with this to find the right liquid. You can precisely measure out the smallest amounts to a 0.1of a milligram. Always crush your 10 Mg pill (NEVER, never, never crush an extended release pill) in 10 mL of liquid and mix well. I would suggest after measuring out your current dose that the balance of the leftover mixture be disgarded. Example: First dose of 10 Mg minus 10% would be equivalent to 9 mL of your liquid mixture Mix well, 10 Mg pill with 10 mL liquid, measure out 9mL with syringe and discard leftover. Next dose minus 10% of 9mL would be approx. 8.1 mL of your liquid mixture (measure the 8mL in your larger syringe and the 0.1mL in your smaller 1.0 mL syringe.) Discard leftover mixture. Next dose 10% of 8.1 mg. would be approx 7.3 mL of your liquid mixture (7 mL in your larger syring and the .3 mL in your smaller 1.0 mL syringe) Discard leftover mixture. Next dose would be 10% of 7.3mg which would be approx 6.6 mL. of your liquid mixture(6 mL in your larger syringe and .6 in your smaller 1.0 mL syringe) Next dose 10% of 6.6Mg would be approx 6 mL. of your liquid mixture Next dose of 10% of 6 Mg would be approx.5.4 mL of your mixture (measure 5mL in your larger syringe and the .4 in your 1.0 mL syringe. Next dose of 10% of 5.4mg would be approx. 4.9 mL of your mixture. Continue your reduction in this manner. Regards, Catherine __________________ Moderator: The technique is likely to be useful for other drugs like Beta-blockers, Ace-Inhibitors, Antidiabetic tablets etc. Quote Link to comment Share on other sites More sharing options...
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