[HealthyIndia] Chelation therapy - Wikipedia, the free encyclopedia

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Namaste, Probably Thomas Riddick was the first to try out the Chelation therapy to cure his blood clotting in the eyes by orally administering citric acid/citrate. Citric acid and other complexing agents have several anionic groups in the molecule and these do two functions. One they increase the negative charge in the colloids in the blood to become more negative and thereby prevent them from clotting. Secondly these chelating agents or the complexing agents complex heavy metals and do the function presented in website quoted by you. In fact Riddick had invented the Zetameter to study how how these anionic agents exert effect on the colloids. The undersigned was fortunate to work with this instrument and publish some papers. SKBSandhirs <nimmiraj61 wrote:  Some recorded facts on Chelation therapy? From Wikipedia Chelation therapy From Wikipedia, the free encyclopedia Jump to: navigation, search Chelation therapy is a process involving the use of chelating agents to remove heavy metals from the body. For the most common forms of heavy metal intoxication, those involving lead, arsenic or mercury, the standard

of care in the US dictates the use of DMSA. This, in addition to other chelating agents such as DMPS and alpha lipoic acid (ALA), are used in conventional medicine; their uses in alternative medicine are highly controversial. Contents 1 Discovery in medicine 2 Uses in conventional medicine 2.1 Examples of chelating agents 3 Uses in alternative medicine 3.1 Heavy metal poisoning 3.2 Heart disease 4 External links [edit] Discovery in

medicine Chelating agents were introduced into medicine as a result of the use of poison gas in World War I. The first widely used chelating agent, dimercaprol, also named British Anti-Lewisite, or BAL, was used as an antidote to the arsenic based poison gas, Lewisite. BAL bound the arsenic in Lewisite, forming a water soluble compound that entered the blood-stream, allowing it to be removed from the body by the kidneys and liver. BAL is an organic di-thiol compound which binds arsenic with two strong chemical bonds formed between the arsenic and the thiols, SH groups, which are also known as "mercaptans". The latter name comes from their ability to react and form strong bonds with, or "capture," mercury - in addition to lead and arsenic. BAL had severe and unpleasant side-effects. After World War II medicine was confronted with a large number of navy personnel who had become occupationally lead poisoned through their jobs repainting the hulls of navy ships. It is at this time that EDTA was introduced into medicine as a lead chelating agent. EDTA is a synthetic amino-acid of different structure from chemicals like BAL. In particular, it contains no mercaptans. While EDTA had some uncomfortable side effects, they were nowhere near as severe as BAL. Subsequent to this, in the 1960s, BAL was modified into DMSA, a related di-thiol with far fewer side effects. DMSA quickly replaced both BAL and EDTA, becoming the US Standard of Care for the treatment of lead, arsenic and mercury poisoning, which it remains today. Research in the ex-Soviet Union lead to the introduction of DMPS, another di-thiol, as a mercury chelating agent. They also introduced ALA, which is transformed by the body into a di-thiol, dihydrolipoic acid, which is a mercury and arsenic chelating agent. DMPS has been given only experimental FDA status in the US. ALA is a common nutritional supplement. Other chelating agents have been discovered. They all have the properties that they bind with

metallic ions so that the ion is held by several chemical bonds and thus render it much less chemically reactive, produce a complex that is water soluble, and thus allow the ion to enter the blood-stream and be excreted harmlessly. [edit] Uses in conventional medicine Heavy metal poisoning is a medical condition usually identified among those occupationally exposed, and which can have significant effects on nearly every organ system [1]. Mercury, for example, has been strongly implicated as "a potential etiological factor in neurodegeneration" [2]. Chelation therapy is used as a treatment for acute mercury, iron, arsenic, lead, plutonium and other forms of heavy metal poisoning, where the amounts are so high that there is enough risk to the health of the patient to justify the therapy. The buildup of iron in thalassemia has led to use in treatment of that disease as well. One example of successful chelation therapy is the case of Harold McCluskey, a nuclear worker who became very badly contaminated internally with americium in 1976. He was treated with diethylene triamine pentaacetic acid (DTPA) over many years to remove americium from his body. While it was not possible to remove all of the americium, it was possible to mitigate the effects of the accident. Harold McCluskey had 41 MBq (1.1 mCi) of 241Am removed from his body, a significant proportion. Harold McCluskey died of unrelated causes 11 years after being contaminated. The chelating agent may be administered intravenously, intramuscularly, or orally, depending on the agent and the type of poisoning. [edit] Examples of chelating agents The choice of chelating agent depends on which metal is involved. Common chelating agents include: Dimercaptosuccinic acid (DMSA) Dimercapto-propane sulfonate (DMPS) Alpha lipoic acid (ALA) Calcium disodium versante (CaNa2-EDTA) D-penicillamine Deferoxamine Defarasirox Dimercaprol (BAL) The calcium

salt of diethylene triamine pentaacetic acid (DTPA) can be used to reduce the amount of plutonium retained in the human body by a factor of about 10 if it is given within about 20 minutes of plutonium entering an open wound. For long term treatment, the zinc salt should be used as this removes fewer vital trace metals from the body. [edit] Uses in alternative medicine There are two general areas of alternative medicine in which chelation is used. One, is in the area of what the practitioners claim to be common but conventionally unrecognized heavy metal poisoning. Such practitioners commonly employ DMSA, DMPS, ALA or EDTA. The second is in the area of heart disease. Such practitioners make use of EDTA. [edit] Heavy metal poisoning Alternative uses of chelating agents for heavy metal poisoning began with the introduction of BAL during the First World War. Certain medical doctors claimed to see substantial lead and arsenic poisoning in their patients due to the heavy use of pesticides. The most common early pesticides were the arsenic based "Paris Green",

later supplanted by lead-arsenate; both of which were extensively used on fruit. BAL, having serious side effects, was given up by both alternative and conventional medicine when alternative appeared. Today DMSA, developed in the US, is the conventional chelating agent of choice. Alternative practitioners make use of this agent; they also make use of DMPS and ALA, both developed in and first studied extensively in the ex-Soviet Union. In addition EDTA, considered by the conventional medical system as an obsolete lead chelating agent with undesireable side effects (though nowhere near as severe as BAL), continues to be used by some alternative practitioners. Furthermore, folklore has given rise to the use of various high sulfur foods as "chelating agents". These include onions, garlic, green foods and sea-weeds. Sulfur supplements like MSM or NAC have also been used. These are not actually chelating agents, as chelators involve double bonds to the

metal atom and these foods and supplements involve compounds that are only mono-thiols. Cilanthro has also been introduced through folklore and is present in numerous alternative medications like "PCA-Rx", "Metal-Free" (both of which also contain ALA) and "NDF". Since no one seems to know what chelating substances may or may not be in cilanthro, and since chelators can be dangerous due to their movement of neurotoxic heavy-metals, they should be approached with caution. What continues to distinguish the alternative practitioner's use of these chelating agents for heavy metal poisoning is that conventional medicine rarely diagnoses heavy metal poisoning outside of occupational medicine. Alternative practitioners claim to recognize extensive environmental exposures, such as through contact with treated lumber. Many of their patients claim to have been exposed to mercury

through their dental amalgam fillings. Others claim that they or their children have become mercury poisoned through the thimerosal, an ethyl-mercury compound used as a preservative in vaccines. Others are treated for mercury, lead or arsenic poisoning of unspecified etiology. As heavy metals are neuro-toxins, any use of chelators, conventional or alternative, should be approached with a great deal of care. [edit] Heart disease Some alternative practitioners use chelation to treat hardening of the arteries. The concept was first introduced by a podiatrist named Palmer from California[citations needed]. The safety and efficacy of EDTA chelation therapy as a treatment for coronary artery disease are being assessed by NCCAM in a five-year study which began in 2002. [3] [4] The original theory behind calcium

chelation therapy was that EDTA forms a complex with the calcium in the walls of arteries. One problem with this theory is that EDTA cannot penetrate the cell walls in the arteries and therefore cannot get access to the calcium. Another is that it binds preferentially to other metals. Finally, it is noted that that calcium has almost no danger in comparison to say, cholesterol. A number of dangers have been associated with the therapy including hypocalcaemia and decreased blood coagulation ability (possibly due to loss of calcium). Also associated with this practice

is the risk of leaching of necessary trace metals. Some alternative practitioners believe intravenous chelation therapy "reverses and slows the progression of atherosclerosis and other age-related and degenerative diseases" [5], such as coronary artery disease and macular degeneration. Some chelation advocates claim that autism, a neurodevelopmental disorder that appears in early childhood, might be caused or aggravated by heavy

metal poisoning and might be ameliorated by chelation therapy, but there is no scientific evidence to support this hypothesis. A private corporation calling itself the American College for Advancement in Medicine (ACAM) claims that 800,000 patient visits for chelation therapy, with an average of forty visits per patient, were made in the United States in 1997 [6]. That is about 0.007% of the total US population. They claim that by 2001 that the number of people who have undergone chelation therapy equaled the number of people having had bypass surgery. A May 2004 survey by the National Center for Complementary and Alternative Medicine (NCCAM) estimated that 0.1%, plus or minus 0.02% of the adult US population had used chelation therapy at some point in their life. In 1998, the U.S. Federal Trade Commission charged that ACAM's Web site and a brochure had made false or unsubstantiated claims. In December 1998, the FTC announced that it had secured a consent agreement barring ACAM from making unsubstantiated advertising claims that chelation therapy is effective against atherosclerosis or any other disease of the circulatory system. The efficacy, safety, and

much of the theory behind these practices are disputed by legitimate scientists. In 2001, researchers at the University of Calgary reported that cardiac patients receiving chelation therapy fared no better than those who received placebo treatment [7]. In August 2005, an autistic boy went into cardiac arrest fifty minutes after undergoing chelation therapy. A coroner's report found that the chelation therapy was the cause.[8] This is the first such case since the 1950s.[9] Dr. Mary Jean Brown, chief of the Lead Poisoning Prevention Branch of the Centers for Disease Control and Prevention, said that the child died because he was given the wrong chelation agent. "It's a case of look-alike/sound-alike medications," she said. "The child was given Disodium EDTA instead of Calcium Disodium EDTA. The generic names are Versinate and Endrate. They sound alike. They're clear and colorless and odorless. They were mixed up."[10] She also quoted from a 1985 Centers for Disease Control statement: "Only Calcium Disodium EDTA should be used. Disodium EDTA should never be used ... because it may induce fatal hypocalcemia, low calcium and tetany." [edit] External links The American College for Advancement in Medicine (ACAM) - alternative medicine organization ExtremeHealthUSA.com Chelation and Nutritional

Replacement Therapy for Chemical & Heavy Metal Toxicity and Cardiovascular Disease Overview Archive.org - 'Chelation Therapy Revolution' (describes use of EDTA as a chelating agent, 1999) NoAmalgam.Com - Book with a good discussion of the dangers of the unconsidered use of chelators. GenerationRescue.org -(parent-led advocacy group promoting use of chelation therapy claiming it is a cure for autism) ScienceDaily.com - 'The Age of Autism: Heavy metal', Dan Olmsted, Science Daily (May 24, 2005) Your-Doctor.com - 'Quack Therapies: Chelation Therapy' (discusses use of chelation therapy in conventional medicine and the hazards of chelation therapy by alternative practitioners) Quackwatch "Chelation Therapy: Unproven Claims and Unsound Theories" by Sam Green Retrieved from "http://en.wikipedia.org/wiki/Chelation_therapy" Categories: Articles with unsourced statements | Medical treatments | Alternative medicine | Pseudoscience Main Page Community Portal Featured articles Current events Recent changes Random article Help Contact Wikipedia Donations Search Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this article In other languages Deutsch Nederlands Polski This page was last modified 19:27, 29 August 2006. All text is available under the terms of the GNU Free Documentation License. (See Copyrights for details.) Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. Privacy

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[Guest guest]

Dear Sunil Babu,

 

I am very happy to know you had a chance to work with the Zetameter.

Can you tell us more about it and your work? What do you do now?

 

Chelation was actually introduced to detoxify soldiers after the

Vietnam War. They had a procedure to rid the body of lead. Currently

this procedure has been modified to chelate mercury.

 

In yesterdays paper it has been reported that the ammunition

manufacturers are going " green " . Bullets will no longer have lead,

tanks will have lesser emission, missiles will have less depleted

uranium and all that. This is not any " humanitarian " gesture but a

tacit admission that the " Gulf War Syndrome " being faced by the US

soldiers is due to their exposure to these elements.

 

Much like mercury being " removed " from vaccines in the USA to " please

the " emotional " parents of vaccine damaged children " .

 

Deny it and then try to take preventive measures try and control the

protests.

 

Regards,

Jagannath.

 

, Sunil Bhattacharjya

<sunil_bhattacharjya wrote:

>

> Namaste,

>

> Probably Thomas Riddick was the first to try out the Chelation

therapy to cure his blood clotting in the eyes by orally

administering citric acid/citrate. Citric acid and other complexing

agents have several anionic groups in the molecule and these do two

functions. One they increase the negative charge in the colloids in

the blood to become more negative and thereby prevent them from

clotting. Secondly these chelating agents or the complexing agents

complex heavy metals and do the function presented in website quoted

by you. In fact Riddick had invented the Zetameter to study how how

these anionic agents exert effect on the colloids. The undersigned

was fortunate to work with this instrument and publish some papers.

>

> SKB

[Guest guest]

Dear Jagannathji,

 

Namaste,

 

I worked with the Zetameter during the period 1973-1975 by importing a

Zetameter from Mr.T.M.Riddick & associates USA throuh my organisation and I have

published several papers including two of them in the Journal of the American

Water Works Association. My work was related to the field of Environmental

Engineering and also related to reducing viscosity of thick slurries by

increasing the anionic charges so that slurry transportation could become

easier. At that time some work was also done at IIT, Kanpur by Dr. Malay

Choudhury and I do not know how long he continued that work thereafter. The

action of anticoagulants like Heparin is also the same mechanism. By studying

the measure of the charge against the doses of the anionic agents one can arrive

at the optimum doses required and this study also throws some light on the

mechanism of their action. Anionic agents also include agents like EDTA

(Ethylene diamine Tetra-acetic acid). These are also very useful for the

treatment of heart patients and that is how the Chelation therapy came to be

used. You will know about these applications better than me as I am not a

medical practitioner. I wonder why chelation therapy has been given the backseat

now. When an artery is injured positive charge develops in that place and

anionic particles of the blood will clot at that place as it happens sometimes

in an operation and that can be remedied by administering these anionic agents.

 

Some of these anionic agents form complexes with heavy metals and could help

in excretion of them. Of course there are other specific complexing agents like

thiols which are specific for mercury and their complexation not necessarily

raises the anionic character.

 

Regards,

 

Sunil Kumar Bhattacharjya

 

 

 

 

 

jagchat01 <jagchat01 wrote:

 

Dear Sunil Babu,

 

I am very happy to know you had a chance to work with the Zetameter.

Can you tell us more about it and your work? What do you do now?