LDL oxidation by arterial wall macrophages/antioxidants

[Guest guest]

Hi Greg,

 

I wrote:

> Aside from vit. E, are there any other antioxidants that specifically

> 'neutralize' free radicals formed from lipid peroxidation?

 

You replied:

Vit E is the main guy, but then you need Vit C to help recycle it.

Anti-oxidants work in teams which pass the free radical down a linked chain

and thus recycle each other (restore anti-oxidant capacity) and you need to

supplement with balanced amount of each or you may break the chain and have

something which should have been a anti-oxidant turning into

pro-oxidant.

 

Me: If you have the patience to give an example of how this works, I would

LOVE to understand this. This is an important concept - how an *anit*oxidant

can become a *pro*oxidant, and I'd really like to understand how that works.

 

 

You:

This happened in a old beta carotene (Vit A precursor) and smoking

experiment. Because they did not supplement in a balanced form, the smokers

feed the beta carotene got elevated rates of cancer instead of the other way

around.

 

Me:

I thought the study was *flawed* because researchers used a synthetic beta

carotene, instead of natural. Thought I had read that. Anyway, no matter - I

can't rely on my memory because I've been reading so much nutrition

literature lately that I can't keep it all straight. I'm glad you reminded

me of how vits C and E work together. That slipped my mind.

 

You:

The anti-oxidants from grape seed are prime examples of this and really do

their magic through recycling Vit C heaps of times and thus make a small

dose of Vit C seem to last forever and have amazing capacity to deal with a

much larger amount of free radicals than the Vit C could by itself.

 

Me:

The funny thing about vit. C is that we are the only mammals who don't

manufacture our own! So, in regards to dosing my dogs, I really have no way

of knowing whether they are synthesizing enough on their own, or if not, how

much they need. I just assume they need some, so I give them food-based Vit.

C with flavanoids, or rosehips 5-6 days week. I also give high doses of vit.

E 5 days/week and OPCs about 3 days/week. Not to mention regular doses of

Glutathione Peroxidase, Catalase, Superoxide Dismutase and Methionine

Reductase, co-q 10, mixed carotenoids and lipoic acid. They're seniors and I

think this wide array of antioxidants are helping to keep them healthy. I

take all these myself, as well. Are there any antioxidants that I didn't

list which you feel is important (for humans)?

 

Are there benefits of consuming certain antioxidants *at the same time*? In

other words, do you have to consume vits E and C at the same meal for

maximum effect, or, do you just need to consume each regularly and achieve

*balance over time*?

 

Thanks for your informative post

 

Suze Fisher

Web Design & Development

http://www.suscom-maine.net/~cfisher/

cfisher

[Guest guest]

-

" Suze Fisher " <cfisher

 

Sunday, January 13, 2002 12:54 AM

LDL oxidation by arterial wall macrophages/antioxidants

 

 

> Me: If you have the patience to give an example of how this works, I would

> LOVE to understand this. This is an important concept - how an *anit*oxidant

> can become a *pro*oxidant, and I'd really like to understand how that works.

 

Hi Suze,

 

Checkout:

http://st14./lib/networkantioxidants/antioxidantnetwork.htm

 

Heaps of other good info on the site.

========================

Good Health & Long Life,

Greg Watson, http://optimalhealth.cia.com.au gowatson

USDA database (food breakdown) http://www.nal.usda.gov/fnic/foodcomp/

PubMed (research papers) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

DWIDP (nutrient analysis) http://www.walford.com/dwdemo/dw2b63demo.exe

Patch file for above http://www.walford.com/download/dwidp67u.exe

KIM (omega analysis) http://ods.od.nih.gov/eicosanoids/KIM_Install.exe