Vitamin E and lipid peroxide plasma levels predict the risk of cardiovascular events in a group of healthy very old people.

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Hi All,

 

The last line says it all:

 

We confirm previous data showing that total cholesterol is NOT a predictor

of cardiovascular disease in people age 80 and older.

 

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1380744 & dopt=Abstract

J Am Geriatr Soc 2001 May;49(5):533-7 Related Articles, Books, LinkOut

Vitamin E and lipid peroxide plasma levels predict the risk of cardiovascular

events in a group of healthy very old

people.

Mezzetti A, Zuliani G, Romano F, Costantini F, Pierdomenico SD, Cuccurullo F,

Fellin R; The Associazione Medica Sabin.

Centro per lo Studio dell'Ipertensione Arteriosa, delle Dislipidemie e

dell'Arteriosclerosi, Department of Medicine and

Aging Science, University G. D'Annunzio, Chieti, Italy.

 

OBJECTIVES:

To assess whether systemic oxidative stress can predict the risk of first

myocardial infarction, ischemic stroke, and

congestive heart failure.

 

DESIGN:

A longitudinal study started in 1992 and completed in 1997.

 

SETTING:

Community-based, outpatient.

 

PARTICIPANTS:

 

102 apparently healthy, community-dwelling subjects age 80 and older from the

Vibrata valley, Teramo, Italy.

 

MEASUREMENTS:

Plasma vitamin E, beta-carotene, vitamin C, fluorescent products of lipid

peroxidation (FPLPs), and serum lipids were

determined at enrollment.

 

RESULTS:

Thirty-two cardiovascular events were recorded in 47.4 months of follow-up. The

subjects with vitamin E levels in the

highest quartile had a risk of cardiovascular events one-sixth those with

vitamin E levels in the lowest quartile

(relative risk (RR) = 0.16; 95% confidence interval (CI) = 0.04-0.55). The

subjects with FPLPs in the highest quartile

had a risk seven times greater than those with FPLPs in the lowest quartile (RR

= 7.61; 95% CI = 2.23-25.96). No

association was observed for vitamin C, beta-carotene, or total cholesterol.

Multivariate adjustment for known risk

factors did not significantly change the results.

 

CONCLUSIONS:

Our results suggest that in apparently healthy, community-dwelling very old

subjects, base-line plasma concentration of

vitamin E and FPLPs predicts the risk of future cardiovascular events.

 

We confirm previous data showing that total cholesterol is not a predictor of

cardiovascular disease in people age 80

and older.

 

PMID: 11380744 [PubMed - indexed for MEDLINE]

 

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Good Health & Long Life,

Greg Watson, gowatson

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