Soy isoflavones--benefits and risks (SERMs)

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1: J Am Coll Nutr 2001 Oct;20(5 Suppl):354S-362S; discussion 381S-383SBooks

Soy isoflavones--benefits and risks from nature's selective estrogen

receptor modulators (SERMs).

Setchell KD.

 

Department of Pediatrics, Children's Hospital Medical Center, Cincinnati,

Ohio 45229, USA. SETCK0

 

Phytoestrogens have become one of the more topical areas of interest in

clinical nutrition. These non-nutrient bioactive compounds are ubiquitous to

the plant kingdom and possess a wide range of biological properties that

contribute to the many different health-related benefits reported for soy

foods and flaxseeds--two of the most abundant dietary sources of

phytoestrogens. Reviewed is the recent knowledge related to their

pharmacokinetics and clinical effects, focusing mainly on isoflavones that

are found in high concentrations in soy foods. Arguments are made for

considering soy isoflavones as natural selective estrogen receptor

modulators (SERMs) based upon recent data of their conformational binding to

estrogen receptors. Rebuttal is made to several key and important issues

related to the recent concerns about the safety of soy and its constituent

isoflavones. This article is not intended to be a comprehensive review of

the literature but merely highlight recent research with key historical

perspectives.

 

PMID: 11603644 [PubMed - in process]

 

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