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Dear Lorenzo,

 

Is Indocid anything like allopinol?

 

Answer evidentially not.;;

 

Allopurinol acts on purine catabolism, without disrupting the biosynthesis

of purines. It reduces the production of uric acid by inhibiting the

biochemical reactions immediately preceding its formation.

 

Allopurinol is a structural analogue of the natural purine base,

hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible

for the conversion of hypoxanthine to xanthine and of xanthine to uric acid,

the end product of purine metabolism in man. Allopurinol is metabolized to

the corresponding xanthine analogue, oxipurinol (alloxanthine), which also

is an inhibitor of xanthine oxidase.

 

It has been shown that reutilization of both hypoxanthine and xanthine for

nucleotide and nucleic acid synthesis is markedly enhanced when their

oxidations are inhibited by allopurinol and oxipurinol. This reutilization

does not disrupt normal nucleic acid anabolism, however, because feedback

inhibition is an integral party of purine biosynthesis. As a result of

xanthine oxidase inhibition, the serum concentration of hypoxanthine plus

xanthine in patients receiving allopurinol for treatment of hyperuricemia is

usually in the range of 0.3 to 0.4 mg/dl compared to a normal level of

approximately 0.15 mg/dl. A maximum of 0.9 mg/dl of these oxypurines has

been reported when the serum urate was lowered to less than 2 mg/dl by high

doses of allopurinol. These values are far below the saturation levels at

which point their precipitation would be expected to occur (above 7 mg/dl).

 

The renal clearance of hypoxanthine and xanthine is at least 10 times

greater than that of uric acid. The increased xanthine and hypoxanthine in

the urine have not been accompanied by problems of nephrolithiasis

************************************

 

.... GENERIC NAME: indomethacin. BRAND NAMES: Indocin, Indocin-SR.

DRUG CLASS AND MECHANISM: Indomethacin ...

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Arthritis Insight

DRUG CLASS AND MECHANISM: Indomethacin is a nonsteroidal anti-inflammatory

drug (NSAID) effective in treating fever, pain, and inflammation in the

body. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain

of many causes, including injury, menstrual cramps, arthritis, and other

musculoskeletal conditions. Since the response to different NSAIDs varies

from patient to patient, it is not unusual for a doctor to try different

NSAIDs for any given condition.

 

PRESCRIPTION

 

Best Regards, Lorenzo

 

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