How unusual cells may hold key to HIV control

[Guest guest]

How unusual cells may hold key to HIV control

 

Rare people who manage to control HIV on their own are offering new

insights into how the immune system kills infected cells.

 

http://www.world-science.net/exclusives/081204_hiv

 

Rare people who manage to control HIV on their own are offering new

insights into how the immune system eliminates virus-infected cells,

researchers say. A study identifies specific qualities of the immune

cells that successfully destroy infected cells and may drive strategies

for developing new HIV vaccines and therapies. The rare individuals

dubbed “long-term nonprogressors†are able to contain

HIV, the virus behind AIDS, for many years without treatment. Evidence

suggests certain virus-specific immune cells, called CD8+ T cells,

confer this ability by destroying virus-infected cells†" but how

remains unknown, said senior study author Mark Connors of the National

Institute of Allergy and Infectious Disease in Bethesda, Md. Using new

tools that precisely measure these cells’ killing capacity,

Connors and colleagues compared how cells from progressors

non-progressors battle the virus. The CD8+ T cells of nonprogressors

clobbered infected cells by successfully dispensing protein molecules

onto them which poked holes in their protective membranes, the

researchers found. The immune cells subsequently delivered a deadly

molecule called granzyme B to the compromised cells. The CD8+ T cells of

progressors accomplished this process poorly, investigators found. But

these diminished abilities were reversible after treatment with certain

compounds, including phorbol ester and calcium ionophore, suggesting

possible therapeutic strategies, they added. The findings could also

“be an extremely important milestone for HIV vaccine

research,†said Stephen Migueles, lead author of the study,

published in the Dec. 4 issue of the research journal Immunity.

[Guest guest]

I wonder how many of these people didn't take the drugs offered by the mad scientists in Bethesda? My now deceased BIL said he knew the night that he contracted hiv in 1986, and he died in 1990. He fit the lifestyle that Duesburg described to a T. They frightened him into taking the drugs. Same with my mother. My mother went to NIH for help with her heart, enrolled in an experimental program, and died of a massive heart attack soon after. A few years later, I read in the Wash Compost that the drugs they were giving people at that time actually caused heart attacks. --- On Tue, 12/9/08, robert-blau <robert-blau wrote:

robert-blau <robert-blau How unusual cells may hold key to HIV control , SymphonicHealth , oleander soup , cancercure , cancercure2 , cancercured , cancer_alternatives , cancervictory , erajan, fjhollerDate: Tuesday, December 9, 2008, 7:35 PM

 

 

How unusual cells may hold key to HIV controlRare people who manage to control HIV on their own are offering newinsights into how the immune system kills infected cells.http://www.world- science.net/ exclusives/ 081204_hivRare people who manage to control HIV on their own are offering newinsights into how the immune system eliminates virus-infected cells,researchers say. A study identifies specific qualities of the immunecells that successfully destroy infected cells and may drive strategiesfor developing new HIV vaccines and therapies. The rare individualsdubbed “long-term nonprogressors� are able to containHIV, the virus behind AIDS, for many years without treatment. Evidencesuggests certain virus-specific immune cells, called CD8+ T cells,confer this ability by destroying

virus-infected cellsâ€"but howremains unknown, said senior study author Mark Connors of the NationalInstitute of Allergy and Infectious Disease in Bethesda, Md. Using newtools that precisely measure these cells’ killing capacity,Connors and colleagues compared how cells from progressorsnon-progressors battle the virus. The CD8+ T cells of nonprogressorsclobbered infected cells by successfully dispensing protein moleculesonto them which poked holes in their protective membranes, theresearchers found. The immune cells subsequently delivered a deadlymolecule called granzyme B to the compromised cells. The CD8+ T cells ofprogressors accomplished this process poorly, investigators found. Butthese diminished abilities were reversible after treatment with certaincompounds, including phorbol ester and calcium ionophore, suggestingpossible therapeutic strategies, they added. The findings could

also“be an extremely important milestone for HIV vaccineresearch,� said Stephen Migueles, lead author of the study,published in the Dec. 4 issue of the research journal Immunity.