Tocotrienols

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Tocotrienols lower cholesterol Mohammad Minhajuddin, PhD, of the University of

Rochester, and colleagues reported in the May 2005 issue of Food and Chemical

Toxicology that tocotrienols from rice brain oil significantly lower total and

low-density lipoprotein cholesterol (LDL). Tocotrienols are four of the eight

members of the vitamin E family, whose benefits have only recently been

explored. Dr Minhajuddin's team fed rats a diet designed to induce

atherosclerosis which more than doubled their cholesterol levels, tripled their

triglyceride levels, and increased their LDL cholesterol by a factor of five

after three weeks. Markers of oxidative damage were also increased. The animals

were then given varying doses of tocotrienol rich fraction from rice bran oil

for one week. It was found that administration of tocotrienols lowered

cholesterol dose-dependently, with the greatest benefit observed at a daily dose

of 8 international units (IU) per kilogram, which is equivalent to a dose of 560

IU for a 154 pound human. Total cholesterol levels were lowered by 42 percent,

and LDL cholesterol by 62 percent. HMG-CoA reductase, an enzyme that is used by

the liver to make cholesterol, was reduced during treatment with tocotrienols,

as well as two of the markers of oxidative damage. -Life Extension

 

Jerry Mittelman, DDS, FAPM - - - Reply with your po box or street address

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