berry seeds vs cancer

[Guest guest]

Berry Good Health By Susan Thorpe-Vargas Ph.D.

 

Multiple studies have discovered that phytonutrients found in raspberries can

protect us from cancer and can even shrink some types of cancer tumors. These

substances can also act as an antibacterial and as an antiviral agent. Does this

sound too good to be true? One particular substance found in this natural

" medicine chest " , is a series of compounds called ellagitannins.

 

The highest levels are found in raspberries, but the ellagitannins are also in

certain types of grapes, strawberries, blackberries, blueberries and some nuts

too. Recent work (2001), published by Dr. Gary Stoner at Ohio State University,

showed that components in the seeds and berry, but particularly ellagitannins,

inhibited the initiation and promotion/progression stages of esophageal cancer.

This is an extremely important finding, considering the potential benefits. We

do not as yet know all of the functions of the ellagitannins in terms of cancer.

 

A study at Hollings Cancer Center, Medical University of South Carolina has

shown one of the ways they work is to " turn on " a normal cellular process called

apoptosis. Apoptosis is " science speak " for something called programmed cell

death. This natural cell death is just one of several ways our body protects us

from cancer. As we age, cellular replication mistakes can occur. Cancer cells

somehow become immune to the signals that cause cells to self-destruct, so they

become virtually immortal and reproduce indefinitely. The disease with a

thousand faces Cancer is not just one disease but is the general name for more

than 200 different types of malignancies. Cancers are classified by the tissue

type from which they arise: * osteosarcoma-bone cancer * melanoma-skin cancer *

lymphoma-cancer of lymph nodes * leukemia - blood cancer Every cellular type has

its own form of cancer.

 

The one thing all cancers share in common is uncontrolled growth. Cancer occurs

when cells lose control over critical checkpoints during the process of one cell

splitting and becoming two cells. This control over cellular replication is in

the hands of several specific types of genes. Two classes of genes are suspected

of being associated with the occurrence of cancer. A mutation in a tumor

suppressor gene is like having faulty brakes in your car. Just as their name

implies, tumor suppressor genes function by making sure there are no mistakes in

the genes that are replicated prior to one cell becoming two. In this " quality

control " process, if errors are detected, the cell is instructed not to divide.

Thus, tumor suppressor genes put the brakes on cellular division. The other

class of genes thought to be involved with preventing cancer is called

proto-oncogenes. Researchers have found that these genes " code " for proteins

involved in mechanisms that regulate the social behavior of cells. Signals from

those cells in the immediate environment induce their neighbors todivide,

differentiate and even undergo apoptosis. So, this type of gene is involved in

promoting the normal growth and division of cells and could be likened to your

car's accelerator.

 

A change in the genetic message - a mutation, can turn the proto-oncogene into

an oncogene and cause your accelerator to become stuck, thus initiating

" runaway " cellular replication. Nevertheless, there seem to be no pattern to

these mutations. What is so frustrating for both researchers and clinicians

alike is that different combinations of mutations are found in different types

of cancer and even in cancers of supposedly the same type in different patients.

What is most important to remember is that cancer begins as a single abnormal

cell that begins to multiply out of control. So, what causes most mutations? We

live in a polluted environment. For instance, the outgassing from asphalt on a

hot summer day produces the deadly carcinogen benzo{a}pyrene, the same chemical

found on meat that has been charcoal broiled. This is just but one example.

Exposure to such chemicals in the environment can cause the mutations in our

genetic material that lead to cancer. Even normal metabolic processes like

breathing and exercise produce free radicals that can wreak havoc on our

cellular DNA. We can protect ourselves from mutations caused by environmental

toxins and free radicals by taking antioxidants. Guess what? Ellagitannins are

also very good antioxidants and chemoprotective agents. Researchers at Wayne

State University have a theory about how ellagitannins might work. The liver

produces enzymes that rid the body of toxins. These enzymes break down or

chemically change toxic substances we ingest or inhale so that they can be

excreted. During this detox process, the breakdown products, called metabolites,

are frequently more damaging then the original substance. It appears that

ellagitannins are able to safeguard the liver from damage caused by these

breakdown products.

 

Another theory held by some investigators is that ellagitannins are able to

protect our genetic material from certain types of chemical reactions that lead

to misreading of damaged DNA. Why does chemotherapy and radiation eventually

stop working? It is becoming clear that normal therapeutic cancer treatment

works by turning on apoptosis. We used to think that chemotherapy and radiation

killed rapidly dividing cells, which is why these procedures were able to shrink

tumors. However, at some point these treatments begin to lose their

effectiveness. Why is that? Scott Lowe, a research scientist at Cold Spring

Harbor Laboratory may have found the answer. Instead of killing these cells,

chemotherapy and radiation damage their cellular DNA. This alerts the cell

watchdogs that control the cell cycle that something is wrong and tells the cell

to stop dividing or to commit suicide. Therefore, chemotherapy and radiation act

somewhat like a " vaccination " that works by helping the body help itself. The

evidence for Dr. Lowe's theory is pretty convincing, because when these

treatments start to fail, researchers have found that the genes that control

apoptosis are no longer functioning. Why don't ellagitannins induce normal cells

to commit suicide? As we know, cancer cells become immortal, this means that

they are able to replicate themselves after something called the Hayflick limit

has beenreached. The Hayflick limit is the number of " allowed " cellular

replications. Each cell type has its own limit. Human cancer studies show that

mutations in the tumor suppressor gene called p53 account for many of the tumors

found. One of the functions of this gene is that it normally prevents cells with

damaged DNA from proceeding through the cell cycle. The presence of the protein

product encoded by p53 turns on the waf-1 gene. The waf-1 gene produces a

protein that normally inhibits the activity of several similar cellular proteins

called kinases. These proteins are involved in stopping cell cycle progression.

A mutation in either the p53 or waf-1 gene can cause the loss of that " emergency

brake " function and allow uncontrolled growth. However, only " damaged " cells are

induced to commit suicide and so normal cells are not effected.

 

An Antibacterial and an Antiviral agent Ellagitannins can act as antibacterial

agents and as antiviral agents too, and now we know how. Think of the genetic

material of bacteria as a rubber band that is all twisted up. In order to

replicate, the DNA must untwist itself through a process requiring the enzyme

gyrase. Ellagitannins inhibits gyrase activity so replication of the bacterial

DNA is restricted. Importantly, bacteria cannot easily become resistant to this

type of antibacterial action. Resistance to antibiotics has become a real

concern to the international medical community. A federal government task force

noted that antibiotic resistance was " a growing menace to all people " but

children, the elderly and those with weakened immune systems are especially at

risk.

 

Besides its antibacterial action, ellagitannins have antiviral activity also.

Viruses do not have the ability to replicate themselves. Instead they must

" hijack " the host cell and insert their own DNA into the host cell genome. This

requires an enzyme called integrase and the ellagitannins inhibit this enzyme

also. Citizen: Heal Thyself. (With apologies to Mr. Hippocrates) People are

turning to alternative forms of medical treatment and prevention. Not only is

the medical delivery system failing but, our costs for health services are

rising at an astronomical rate. What this means for the medical consumer is that

we need to be more responsible for our own health. We need to look at prevention

instead of always looking to health care providers to " fix " what exposure to a

toxic environment and/or years of unhealthy lifestyle practices have wrought.

The quality of medical care is uneven at best.

 

Too often, our insurance providers do not cover necessary tests and procedures,

especially those of a preventative nature. However, we can become involved in

our own health care. A diet rich in fresh fruits and vegetables is a good start

towards preventing disease. Unfortunately, current tests show that our soil is

severely lacking in many minerals or electrolytes and other components that are

essential for proper nutrition. It is necessary to sometimes take supplements as

it may not be physically or economically possible to eat enough food to get the

proper nutrition. In addition, the cost of fresh fruits and vegetables can be

prohibitive. For instance, unless you grow your own raspberries, the cost of the

American Cancer Institute's recommended daily bowl of the whole berries could

run as high as $300 a month. Not only that, but research has shown that the

ellagitannin content is much higher in the seeds then in the fruit.

Sonutraceutical supplements may be the answer. Raspberry seeds contain many more

times the ellagic acid than the fruit at one-tenth the cost. It's your choice,

whatever form you may decide to use- the take home message is: " Eat your

ellagitannins. " ---

 

Jerry Mittelman, DDS, FAPM

 

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What dentists aren't likely to learn in dental school