Exercise

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Mark ---

Here's more for you,

Jerry Mittelman, DDS, FAPM:

Mild Exercise Protects Mature Mice From Flu Death

Posted on Thursday, October 07, 2004 @ 7:00 PM

PDT by bjs

 

 

Researchers report that four consecutive days of moderate

exercise in mice after they were infected with influenza protects them from

dying, compared with mice that didn't exercise. This protective effect was

more evident in mice greater than 16 weeks of age, an age at which they are

immunologically more mature. The takeaway message: exercise regularly

because you never know when you'll be exposed!

 

From American Physiological Society :

 

After Flu Exposure, Mild Exercise Protects Mature Mice

From Dying, But Not From Developing Symptoms

 

Takeaway message: Exercise regularly to stay healthy

 

University of Illinois researchers report that four

consecutive days of moderate exercise in mice after they were infected with

influenza protects them from dying, compared with mice that didn't exercise.

This protective effect was more evident in mice greater than 16 weeks of

age, an age at which they are immunologically more mature. The takeaway

message: exercise regularly because you never know when you'll be exposed!

 

Jeffrey A. Woods, PhD., and graduate student Tom Lowder at

the Physical Fitness Laboratory, Department of Kinesiology, University of

Illinois, Urbana, said their lab has a long-time interest in exercise and

its influence on the immune system. (See ''Exercise delays allogeneic tumor

growth and reduces intratumoral inflammation and vascularization,'' by Mark

R. Zielinski et al., Journal of Applied Physiology, June 2004, published by

the American Physiological Society.)

 

''We had completed a lot of in vitro studies, but we

wanted to study now how exercise affected animals against a real infectious

challenge,'' Woods said. The question they addressed in their study,

''Protective effect of exercise on mortality due to influenza in mice,'' was

''can exercise protect against morbidity and mortality?'' While exercise

protected mice from mortality, it didn't seem to have any affect on gross

measures of sickness behavior like food intake and cage activity.

 

Editors note: Woods and Lowder are reporting their

findings at the American Physiological Society's 2004 Intersociety Meeting,

''The Integrative Biology of Exercise,'' Oct. 6-9 in Austin. The meeting

schedule can be found at

(http://www.the-aps.org/meetings/aps/austin/tentative.pdf). The complete

program, including abstracts, for the entire meeting is available upon

request to members of the media.

 

Arrangements for on-site interviews, or telephone

interviews during the meeting can be arranged through APS Communications

Officer Mayer Resnick (cell: 301.332.4402, mresnick) or through

Stacy Brooks, APS Communications Specialist,

 

301.634.7253. From Oct. 6 (2p.m.) - Oct. 9, the onsite

phone number is 512.482.8000, room 602, or 512.681.2950.

 

Daily exercise until symptoms are present

 

Male mice 11-20 weeks old were infected with influenza

virus and then randomly assigned to exercise (EX) or home cage control

(HCC). The EX mice were exercised for 20 to 30 minutes for four days and

multiple subjective and standard measurements were recorded.

 

''The animals did very moderate exercise while they were

mounting an immune response,'' Woods noted. As soon as symptoms appeared,

exercise was stopped, to mirror how most people react once they come down

with flu-like symptoms. The mice were naïve, that is, they previously hadn't

been exercising on a regular basis.

 

Results both striking and surprising; human flu vaccine

reaction study underway

 

20-week-old mice that had exercised had significantly

(p=0.008) higher survival rates (18 of 22) versus HCC of the same age (10 of

22). However, 11- to 16-week-old mice didn't show a significantly higher

survival rate. When all EX mice (47) were compared with all HCC mice (48),

EX had twice the survival rate, 59% vs. 29.4% (p=0.003). None of the

variables (food/water intake, random activity or symptom severity) proved to

be reliable at predicting mortality. However, severe lethargy was apparent

one to two days prior to death. And while there was a ''marked,

age-dependent effect on mortality, there was no effect at all on morbidity,

which was somewhat surprising,'' Woods said.

 

The Illinois researchers plan on doing followup studies

with animals that had been exercising regularly, as well as studies that to

try and uncover the overall protective effect and its mechanisms. Areas that

they'll be studying include: lung histopathology, cytokine gene and protein

expression in the lung, and possible development of flu-specific immune

cells.

 

At the moment, the laboratory also has a large NIH-funded

human clinical trial underway examining whether or not moderate exercise

training can improve immunological vigor --including responses to influenza

vaccine -- in older adults.

 

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>

> Hey Jerry do you have the specific reference for this? I am writing a very

> strong piece combining the medical terrorism of both flu and hep b

vaccines

> and the fact that the viruses to both, under healthy conditions, offer

> little threat to human beings.

>