Apricot pits - some efectiveness

[Guest guest]

Good morning ! I have a friend in the nutrition field who has recomended

apricot pits . They have been found to be somewhat effective .

Ellagic Acid from Meeker Raspberries has been found to be more effective

..

 

Thanks john Houser

The Nu herb shop

 

ellagic acid (EA) and quercetin against N-nitrosodiethylamine-induced

lung tumorigenesis in mice. Ellagic acid was able to significantly reduce

tumour incidence to 20% from the control value of 72.2%. Similarly,

tumour burden was also decreased, although not significantly, from 3.15

to 2.5. Quercetin (QR) caused the tumour incidence to decrease from 76.4%

to 44.4% when fed until the third dose of carcinogen. Both of the

polyphenols suppressed the tumour incidence mainly by acting at the

initiation phase of the carcinogenesis, since continuing the feeding of

polyphenols until the termination of the experiment did not cause any

apparent change in tumour incidence or tumour burden. Besides this,

ellagic acid was found to be a better chemopreventor than quercetin. In

order to search for their mechanism of action, the effect of feeding of

these compounds on reduced glutathione (GSH), an important endogenous

antioxidant, and on lipid peroxidation was investigated. Both ellagic

acid and QR caused a significant increase in GSH and decrease in NADPH-

and ascorbate-dependent lipid peroxidation. Ellagic acid was found to be

more effective in decreasing the lipid peroxidation and increasing the

GSH. This may be one of the reasons for its observed better

anticarcinogenic property as compared to quercetin.

MESH TERMS: Animal

Anticarcinogenic Agents/*Therapeutic Use

Chemoprevention

Diethylnitrosamine/*Antagonists and Inhib

Ellagic Acid/*Therapeutic Use

Glutathione/Metabolism

Lipid Peroxidation/Drug Effects

Lung Neoplasms/*Prevention and Control

Male

Mice

Microsomes/Drug Effects/Metabolism

Oxidation-Reduction

Quercetin/*Therapeutic Use

LANGUAGE: ENG

PUBLICATION TYPE: JOURNAL ARTICLE

TITLE ABBREVIATION: Food Chem Toxicol

YEAR: 1999