Wheat and Milk Converting to Opiates

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Wed, 24 Sep 2003 14:21:28 EDT

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Wheat and Milk Converting to Opiates

 

I came across this. It is the earliest research showing that wheat and milk

may covert into opiates resulting in mental disturbance.

Dan

http://www.jbc.org/cgi/content/abstract/254/7/2446

From the Journal of Biological Chemistry

JBC, Vol. 254, Issue 7, 2446-2449, Apr, 1979

Opioid peptides derived from food proteins. The exorphins

C. Zioudrou, R. A. Streaty and W. A. Klee

 

Peptides with opioid activity are found in pepsin hydrolysates of wheat

gluten and alpha-casein. The opioid activity of these peptides was

demonstrated by

use of the following bioassays: 1) naloxone-reversible inhibition of

adenylate

cyclase in homogenates of neuroblastoma X-glioma hybrid cells; 2)

naloxone-reversible inhibition of electrically stimulated contractions of

the mouse vas

deferens; 3) displacement of [3H]dihydromorphine and [3H-Tyr,

dAla2]met-enkephalin amide from rat brain membranes. Substances which

stimulate adenylate

cyclase and increase the contractions of the mouse vas deferens but do not

bind to

opiate receptors are also isolated from gluten hydrolysates. It is suggested

that peptides derived from some food proteins may be of physiological

importance.