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WORRIERS MORE PRONE TO CANCER

By Raj Persaud

New Scientist

May 28, 2003

 

http://www.newscientist.com/news/news.jsp?id=ns99993767

 

It is not the kind of news that will help matters. A study involving

over 60,000 people suggests that people prone to anxiety are more likely to get

cancer.

 

The findings will add to the controversy over whether purely

psychological factors such as stress, anxiety and depression can trigger cancer.

Part of the problem with this kind of study is that it is hard to exclude with

certainty the influence of behavioural factors, such as lack of self-care, poor

diet and smoking.

 

A team of psychiatrists led by Arnstein Mykletun at the University

of Bergen in Norway followed up 62,591 people who took part in a massive medical

survey of people living in one county in Norway during 1995 to 1997. The Norway

National Cancer Registry was used to identify participants in the survey who had

developed cancers or premalignancies -- abnormal cells that can turn cancerous.

 

Those who scored highly in an anxiety test in 1995 were about 25 per

cent more likely to have premalignancies, the team told a meeting of the

American Psychiatric Association in San Francisco last week.

 

Inconsistent results

 

Previous studies of the link between mind and cancer have produced

inconsistent results, Susanne Oksbjeg Dalton's team at the Institute

of Cancer Epidemiology in Copenhagen, Denmark, concluded in the most recent

review. But two studies did find an association between

psychological stress and two specific types of tumours, lymphomas and malignant

melanomas.

 

These results are intriguing, as lymphomas and melanomas are linked

with immune system dysfunction. One theory is that psychological states like

stress, anxiety or depression lower immune activity, compromising the body's

constant surveillance for premalignant or cancerous cells, and thus allowing

cancers to grow.

 

Support for this theory comes from another study presented at the San

Francisco meeting. Sandra Nunes's team at the State University of

Londrina in Brazil compared 40 depressed adults who were not on medication with

34 healthy controls.

 

In the depressed patients, there were dramatic reductions in immune

functions, including white blood cell activity and antibody

responses. However, Mykletun's team did not find a statistically significant

link between depression and premalignancies in the Norwegian study, as they did

with anxiety. Dalton also points out that it is vital that factors like smoking

are adequately controlled for in research of this type.

 

People suffering psychological stress are more likely to smoke, greatly

increasing their risk of cancer. Mykletun's team did try to take this into

account, but screening for smokers and determining how much they smoke is

difficult in large studies like the Norwegian one.

 

The debate looks set to run and run. Until it is resolved, anxious

people will have one more thing to worry about.

 

 

 

 

 

 

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