Guest guest Posted February 7, 2007 Report Share Posted February 7, 2007 Does anyone have suggestions of how to deal with the above. Ta Mark Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 7, 2007 Report Share Posted February 7, 2007 It usually indicates dehydration - is the patient well hydrated & drinking 2 - 3 litres of water a day? Jane "mark" > Does anyone have suggestions of how to deal with the above. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2007 Report Share Posted February 8, 2007 ayurveda, "mark" <veganman1961 wrote: > > Does anyone have suggestions of how to deal with the above. > Ta > Mark > Hi Mark This is not a difficult condition to address, and mostly relates to factors such as poor diet, poor food combining, and a lack of fiber, as well as anything that increase intra-abdomnal pressure after eating, such as bending over or tight clothers, or more chronic issues such as constipation and abdominal obesity. It is not difficult to treat once the cause(s) are addressed. Please refer to message # 2189: http://health.ayurveda/message/2189 One thing you don't want to do is shut down acid production since the real issue isn't excess acid, its acid in the wrong place, ie. in the esophagus. An interesting paper that shows that typical drugs such as Nexium (the purple pill) may in fact PROMOTE esophageal cancer: Acid has antiproliferative effects in nonneoplastic Barrett's epithelial cells. Feagins LA, Zhang HY, Hormi-Carver K, Quinones MH, Thomas D, Zhang X, Terada LS, Spechler SJ, Ramirez RD, Souza RF Am J Gastroenterol. 2007 Jan;102(1):10-20 OBJECTIVES: For patients with Barrett's esophagus, physicians commonly prescribe antisecretory medications in dosages above those required to heal reflux esophagitis because acid has been shown to have proproliferative and antiapoptotic effects on Barrett's cancer cells and on Barrett's mucosal explants. For a number of reasons, these model systems may not be ideal for determining the effects of acid on benign Barrett's epithelial cells, however. We studied the effects of acid on proliferation and apoptosis in a nonneoplastic, telomerase-immortalized Barrett's epithelial cell line. METHODS: Barrett's cells were treated with two 3-minute exposures to acidic media. Cell growth was determined using cell counts, proliferation was studied by flow cytometry, cell viability was determined by trypan blue staining, and apoptosis was assessed by TUNEL and Annexin V. The expression levels of p53 and p21 were determined by Western blotting. p53 siRNA was used to study the effect of p53 inhibition on total cell numbers after acid exposure. RESULTS: Acid exposure significantly decreased total cell numbers at 24 h without affecting either cell viability or apoptosis. Acid exposure resulted in cell cycle prolongation that was associated with greater expression of p53, but not p21. The acid-induced decrease in total cell numbers was abolished by p53 RNAi. CONCLUSIONS: Acid exposure has p53-mediated, antiproliferative effects in nonneoplastic Barrett's epithelial cells. These findings contradict the results of prior in vitro and ex vivo studies. We speculate that the prescription of antisecretory medications in dosages beyond those required to heal gastroesophageal reflux disease (GERD) symptoms and endoscopic signs could be detrimental. Controlled, prospective clinical trials are needed to determine the optimal level of acid suppression for patients with Barrett's esophagus. Quote Link to comment Share on other sites More sharing options...
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