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It usually indicates dehydration - is the patient well hydrated & drinking

2 - 3 litres of water a day?

 

Jane

 

"mark"

 

> Does anyone have suggestions of how to deal with the above.

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ayurveda, "mark" <veganman1961 wrote:

>

> Does anyone have suggestions of how to deal with the above.

> Ta

> Mark

>

 

Hi Mark

 

This is not a difficult condition to address, and mostly relates to factors such as poor diet,

poor food combining, and a lack of fiber, as well as anything that increase intra-abdomnal

pressure after eating, such as bending over or tight clothers, or more chronic issues such

as constipation and abdominal obesity. It is not difficult to treat once the cause(s) are

addressed. Please refer to message # 2189:

 

http://health.ayurveda/message/2189

 

One thing you don't want to do is shut down acid production since the real issue isn't

excess acid, its acid in the wrong place, ie. in the esophagus.

 

An interesting paper that shows that typical drugs such as Nexium (the purple pill) may in

fact PROMOTE esophageal cancer:

 

Acid has antiproliferative effects in nonneoplastic Barrett's epithelial

cells.

 

Feagins LA, Zhang HY, Hormi-Carver K, Quinones MH, Thomas D, Zhang X,

Terada LS, Spechler SJ, Ramirez RD, Souza RF

 

Am J Gastroenterol. 2007 Jan;102(1):10-20

 

OBJECTIVES: For patients with Barrett's esophagus, physicians commonly

prescribe antisecretory medications in dosages above those required to heal

reflux esophagitis because acid has been shown to have proproliferative and

antiapoptotic effects on Barrett's cancer cells and on Barrett's mucosal

explants. For a number of reasons, these model systems may not be ideal for

determining the effects of acid on benign Barrett's epithelial cells,

however. We studied the effects of acid on proliferation and apoptosis in a

nonneoplastic, telomerase-immortalized Barrett's epithelial cell line.

METHODS: Barrett's cells were treated with two 3-minute exposures to acidic

media. Cell growth was determined using cell counts, proliferation was

studied by flow cytometry, cell viability was determined by trypan blue

staining, and apoptosis was assessed by TUNEL and Annexin V. The expression

levels of p53 and p21 were determined by Western blotting. p53 siRNA was

used to study the effect of p53 inhibition on total cell numbers after acid

exposure. RESULTS: Acid exposure significantly decreased total cell numbers

at 24 h without affecting either cell viability or apoptosis. Acid exposure

resulted in cell cycle prolongation that was associated with greater

expression of p53, but not p21. The acid-induced decrease in total cell

numbers was abolished by p53 RNAi. CONCLUSIONS: Acid exposure has

p53-mediated, antiproliferative effects in nonneoplastic Barrett's

epithelial cells. These findings contradict the results of prior in vitro

and ex vivo studies. We speculate that the prescription of antisecretory

medications in dosages beyond those required to heal gastroesophageal reflux

disease (GERD) symptoms and endoscopic signs could be detrimental.

Controlled, prospective clinical trials are needed to determine the optimal

level of acid suppression for patients with Barrett's esophagus.

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