Guest guest Posted April 9, 2004 Report Share Posted April 9, 2004 Some snippets an academic source about Mustard oil: Source: http://www.nature.com/cgi-taf/DynaPage.taf? file=/nature/journal/v427/n6971/abs/nature02282_fs.html Nature \ 427, 260 - 265 (15 January 2004); doi:10.1038/nature02282 Nature AOP, published online 7 January 2004 ------------- Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 ------- SVEN-ERIC JORDT1, DIANA M. BAUTISTA1, HUAI-HU CHUANG1, DAVID D. MCKEMY1, PETER M. ZYGMUNT3, EDWARD D. HÖGESTÄTT3, IAN D. MENG2,* & DAVID JULIUS1 1 Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143-2140, USA 2 Department of Neurology, University of California, San Francisco, California 94143-2140, USA 3 Department of Clinical Pharmacology, Institute of Laboratory Medicine, Lund University Hospital, SE-221 85 Lund, Sweden * Present address: Department of Physiology, College of Osteopathic Medicine, University of New England, 11 Hills Beach Road, Biddeford, Maine 04005, USA Correspondence and requests for material should be addressed to D.J. (julius). Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory nerve endings, thereby producing pain, inflammation and robust hypersensitivity to thermal and mechanical stimuli. Despite their widespread use in both the kitchen and the laboratory, the molecular mechanism through which isothiocyanates mediate their effects remains unknown. Here we show that mustard oil depolarizes a subpopulation of primary sensory neurons that are also activated by capsaicin, the pungent ingredient in chilli peppers, and by 9-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Both allyl isothiocyanate and THC mediate their excitatory effects by activating ANKTM1, a member of the TRP ion channel family recently implicated in the detection of noxious cold. These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors. ---------------------------- © 2004 Nature Publishing Group Privacy Policy ************* Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2004 Report Share Posted April 9, 2004 Thanks SO much for this, beloved Sister Sy! Your loving sis. , "Simone" <syzenith>= wrote: > Some snippets an academic source about Mustard oil: > > > Source: http://www.nature.com/cgi-taf/DynaPage.taf? > file=/nature/journal/v427/n6971/abs/nature02282_fs.html > > Nature \ 427, 260 - 265 (15 January 2004); doi:10.1038/nature02282 > Nature AOP, published online 7 January 2004 > > ------------- > Mustard oils and cannabinoids excite sensory nerve fibres through > the TRP channel ANKTM1 > ------- > > SVEN-ERIC JORDT1, DIANA M. BAUTISTA1, HUAI-HU CHUANG1, DAVID D. > MCKEMY1, PETER M. ZYGMUNT3, EDWARD D. HÖGESTÄTT3, IAN D. MENG2,* & > DAVID JULIUS1 > > 1 Department of Cellular and Molecular Pharmacology University of > California, San Francisco, California 94143-2140, USA > 2 Department of Neurology, University of California, San Francisco, > California 94143-2140, USA > 3 Department of Clinical Pharmacology, Institute of Laboratory > Medicine, Lund University Hospital, SE-221 85 Lund, Sweden > * Present address: Department of Physiology, College of Osteopathic > Medicine, University of New England, 11 Hills Beach Road, Biddeford, > Maine 04005, USA > > Correspondence and requests for material should be addressed to D.J. > (julius@c...). > > Wasabi, horseradish and mustard owe their pungency to isothiocyanate > compounds. Topical application of mustard oil (allyl isothiocyanate) > to the skin activates underlying sensory nerve endings, thereby > producing pain, inflammation and robust hypersensitivity to thermal > and mechanical stimuli. Despite their widespread use in both the > kitchen and the laboratory, the molecular mechanism through which > isothiocyanates mediate their effects remains unknown. Here we show > that mustard oil depolarizes a subpopulation of primary sensory > neurons that are also activated by capsaicin, the pungent ingredient > in chilli peppers, and by 9-tetrahydrocannabinol (THC), the > psychoactive component of marijuana. Both allyl isothiocyanate and > THC mediate their excitatory effects by activating ANKTM1, a member > of the TRP ion channel family recently implicated in the detection > of noxious cold. These findings identify a cellular and molecular > target for the pungent action of mustard oils and support an > emerging role for TRP channels as ionotropic cannabinoid receptors. > > ---------------------------- > © 2004 Nature Publishing Group > Privacy Policy > > ************* Quote Link to comment Share on other sites More sharing options...
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