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Preparation of Sodium Ascorbate for IV and IM Use

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Preparation of Sodium Ascorbate for IV and IM Use

(For M.D.'s only)

ROBERT F. CATHCART III, M.D.

ALLERGY, ENVIRONMENTAL & ORTHOMOLECULAR MEDICINE

127 SECOND STREET, SUITE 4 LOS ALTOS, CALIFORNIA 94022

(650) 949-2822

FAX (650) 949-5083

Note: the following are excerpts from letters sent to physicians on the subject

of IVC.

If one does not want to make their sodium ascorbate stock solutions from scratch

like I recommend (and I can well understand why you might not): You can order

from

Merit Pharmaceuticals, 2611 San Fernando, Los Angeles, CA 90065,

For CA 800-696-3748; Out-of State 800-421-9657

To order the Sodium Ascorbate Fine Crystals (specify Roche)

Wholesale Nutrition 915 S. San Tomas Equino Road, Campbell, CA 95008

order 800-325-2664 or FAX 408-867-6236

The Stock Bottle of Sodium Ascorbate

Sterilize a 500 cc IV bottle along with a funnel, the rubber stopper, and a

spoon. Then fill the bottle to the 300 cc line with sodium ascorbate fine

crystals. (I weighed the sodium ascorbate out one time and 250 gm came up to the

300 cc line.) Then add 1/3 of the 20 ml bottle (6.6 cc) of edetate disodium

injection, USP 150 mg/ml. Then add water for injection q.s. 500 cc. Shake up the

bottle and if there is 1 mm of crystals left on the bottom, add 1 mm of water to

the top. It turns out that sodium ascorbate is soluble to almost exactly a 50%

concentration at room temperature. I do not worry about the sterility of this

because this is very bacteriocidal. Perhaps it should be filtered to get out

particulate matter but I have never seen this to be a problem. The pH of this

has always turned out to be 7.4. My nurse discovered recently that if you do not

shake the mixture to make it go into solution until after you refrigerate it and

are ready to use it that the solution is less yellow. I

presume that this is good because sodium ascorbate is clear and

dehydroascorbate is yellow. The made up solutions are always a little yellow but

refrigeration before mixing results in a far less yellow mixture.

Preparation of the IV Bottle

I recommend that the above stock bottle solution be added to lactated Ringer's

such that 30 Gms (60 cc) to 60 Gms (120 cc) this be added to a quantity of

lactated Ringer's sufficient to make 500 cc of the final solution to be injected

IV. I had been using water for injection some time ago because this solution is

several times hypertonic already and I did not want to add more tonicity.

However, recently I have found that lactated Ringer's feels better to patients

so I use that for the final dilution (not the stock solution described above.)

IM Injections

IM injection material for infants is made from the stock solution diluted 50% in

water giving a 25% solution. Generally, the size of the injection can be 2 cc in

each buttocks. Ice may be applied if it hurts to much. This may be given every

hour or so, frequently enough to bring the fever or other symptoms of excessive

free radicals down rapidly.

General Comments

I have not had any trouble with these solutions. I hear all sorts of weird

stories from patients who have gotten ascorbate elsewhere. I do not know if it

is an acid problem (because ascorbic acid was used rather than sodium ascorbate)

or whether some colleges get carried away with what other things they add to the

intravenous solutions.

I think that there may be, at times minor troubles with commercially prepared

solutions because of the following. I understand that the U. S. Pharmacopeia

specifies that the solutions be made from ascorbic acid and then buffered with

sodium hydroxide or sodium bicarbonate to a pH between 3.5 and 7.0. I worry that

60 grams of ascorbate at a pH of 3.5 is too acid. I know that Klenner (the first

physician who used high dose intravenous ascorbate by vein) also made his

solutions from sodium ascorbate powder.

I watch patients for hypocalcemia (although I have not seen it), hypoglycemia (I

encourage patients to eat while taking the IV), and dehydration (I encourage

water and slow the IV down.) I also see headaches afterward but not so much

since I have been emphasizing the continuing high doses of oral ascorbic acid as

soon as the IV is over. Actually I give oral ascorbic acid while the IV is going

to get a double effect. Bowel tolerance goes up while the IV is running but one

has to be careful to stop giving oral C about an hour before the IV stops or

else you may get diarrhea as soon as the IV stops. The oral ascorbic acid is

then started again 1/2 to 1 hour after the IVC stops.

Subscribe to the Orthomolecular Mailing List, for doctors, biochemists, and

allied professionals. Write to Webmaster.

 

Copyright © 1996, Robert F. Cathcart, M.D.. Permission granted to distribute

as long as distributed intact and with this attribution.

 

 

 

 

 

 

 

 

 

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